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  3. Unveiling the Impact of BMP9 in Liver Diseases: Insights into Pathogenesis and Therapeutic Potential

Unveiling the Impact of BMP9 in Liver Diseases: Insights into Pathogenesis and Therapeutic Potential

  • Biomolecules. 2024 Aug 15;14(8):1013. doi: 10.3390/biom14081013.
Han Chen 1 2,  Ying-Yi Li 3,  Kouki Nio 3,  Hong Tang 1 2
Affiliations

Affiliations

  • 1 Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
  • 2 Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
  • 3 Department of Gastroenterology, Kanazawa University Hospital, Kanazawa 9208641, Japan.
PMID: 39199400 DOI: 10.3390/biom14081013
Abstract

Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor β(TGF-β) family. While initially recognized for their role in bone formation, BMPs have emerged as significant players in liver diseases. Among BMPs with various physiological activities, this comprehensive review aims to delve into the involvement of BMP9 specifically in liver diseases and provide insights into the complex BMP signaling pathway. Through an enhanced understanding of BMP9, we anticipate the discovery of new therapeutic options and potential strategies for managing liver diseases.

Keywords

BMP signaling; BMP9; liver cancer; liver disease; liver fibrosis.

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