2. Academic Validation
  3. Intra-Articular Injectable Biomaterials for Cartilage Repair and Regeneration

Intra-Articular Injectable Biomaterials for Cartilage Repair and Regeneration

  • Adv Healthc Mater. 2024 Jul;13(17):e2303794. doi: 10.1002/adhm.202303794.
Manivannan Sivaperuman Kalairaj 1,  Ridhi Pradhan 1,  Waqas Saleem 1,  Morgan M Smith 2,  Akhilesh K Gaharwar 1 3 4
Affiliations

Affiliations

  • 1 Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, 77843, USA.
  • 2 Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.
  • 3 Department of Material Science and Engineering, College of Engineering, Texas A&M University, College Station, TX, 77843, USA.
  • 4 Genetics and Genomics Interdisciplinary Program, Texas A&M University, College Station, TX, 77843, USA.
PMID: 38324655 DOI: 10.1002/adhm.202303794
Abstract

Osteoarthritis is a degenerative joint disease characterized by cartilage deterioration and subsequent inflammatory changes in the underlying bone. Injectable hydrogels have emerged as a promising approach for controlled drug delivery in cartilage therapies. This review focuses on the latest developments in utilizing injectable hydrogels as vehicles for targeted drug delivery to promote cartilage repair and regeneration. The pathogenesis of osteoarthritis is discussed to provide a comprehensive understanding of the disease progression. Subsequently, the various types of injectable hydrogels used for intra-articular delivery are discussed. Specifically, physically and chemically crosslinked injectable hydrogels are critically analyzed, with an emphasis on their fabrication strategies and their capacity to encapsulate and release therapeutic agents in a controlled manner. Furthermore, the potential of incorporating growth factors, anti-inflammatory drugs, and cells within these injectable hydrogels are discussed. Overall, this review offers a comprehensive guide to navigating the landscape of hydrogel-based therapeutics in osteoarthritis.

Keywords

biomaterials; drug delivery; hydrogels; injectable; osteoarthritis.

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