2. Academic Validation
  3. The potential of marine-derived piperazine alkaloids: Sources, structures and bioactivities

The potential of marine-derived piperazine alkaloids: Sources, structures and bioactivities

  • Eur J Med Chem. 2024 Feb 5:265:116081. doi: 10.1016/j.ejmech.2023.116081.
Zilong Zhang 1,  Yu Sun 2,  Yiming Li 3,  Xiaomei Song 4,  Rui Wang 5,  Dongdong Zhang 6
Affiliations

Affiliations

  • 1 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, PR China. Electronic address: zhang1040191907@163.com.
  • 2 School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, PR China. Electronic address: XJZXY0707@163.com.
  • 3 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China. Electronic address: ymlius@163.com.
  • 4 School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, PR China. Electronic address: songxiaom@126.com.
  • 5 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China. Electronic address: ellewang@163.com.
  • 6 School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, PR China. Electronic address: zhangnatprod@163.com.
PMID: 38181652 DOI: 10.1016/j.ejmech.2023.116081
Abstract

Marine-derived piperazine Alkaloids (MDPAs) constitute a significant group of natural compounds known for their diverse structures and biological activities. Over the past five decades, substantial efforts have been devoted to isolating these Alkaloids from marine sources and characterizing their chemical and bioactive profiles. To date, a total of 922 marine-derived piperazine Alkaloids have been reported from various marine organisms. These compounds demonstrate a wide range of pharmacological properties, including cytotoxicity, Antibacterial, Antifungal, Antiviral, and various Other activities. Notably, among these activities, cytotoxicity emerges as the most prominent characteristic of marine-derived piperazine Alkaloids. This review also summarizes the structure-activity relationship (SAR) studies associated with the cytotoxicity of these compounds. In summary, our objective is to provide an overview of the research progress concerning marine-derived piperazine Alkaloids, with the aim of fostering their continued development and utilization.

Keywords

Bioactivity diversity; Chemical diversity; Cytotoxicity; Piperazine alkaloids.

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