2. Academic Validation
  3. Comparative Analysis of Secondary Metabolites in Diplodia corticola Strains with Different Virulence Degrees Associated with Canker and Dieback of Quercus spp

Comparative Analysis of Secondary Metabolites in Diplodia corticola Strains with Different Virulence Degrees Associated with Canker and Dieback of Quercus spp

  • Molecules. 2023 Aug 28;28(17):6302. doi: 10.3390/molecules28176302.
Maria Michela Salvatore 1 2,  Maria Teresa Russo 1,  Rosario Nicoletti 3 4,  Alla Eddine Mahamedi 5,  Akila Berraf-Tebbal 6,  Alessio Cimmino 1 7,  Marco Masi 1 7,  Anna Andolfi 1 7
Affiliations

Affiliations

  • 1 Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
  • 2 Institute for Sustainable Plant Protection, National Research Council, 80055 Portici, Italy.
  • 3 Department of Agriculture, University of Naples Federico II, 80055 Portici, Italy.
  • 4 Council for Agricultural Research and Economics, Research Center for Olive, Fruit and Citrus Crops, 81100 Caserta, Italy.
  • 5 Department of Biology, Faculty of Natural Sciences, Life and Earth Sciences, University of Ghardaïa, Ghardaïa 47000, Algeria.
  • 6 Mendeleum-Institute of Genetics and Plant Breeding, Faculty of Horticulture, Mendel University in Brno, 69144 Lednice, Czech Republic.
  • 7 BAT Center-Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology, University of Naples Federico II, 80055 Portici, Italy.
PMID: 37687130 DOI: 10.3390/molecules28176302
Abstract

Diplodia corticola is one of the most aggressive Fungal pathogens of Quercus species involved in the decline of Mediterranean oak forests. In this study, three strains of D. corticola associated with holm (Quercus ilex) and cork (Quercus suber) oak trees exhibiting dieback symptoms and cankers in Algeria were selected to investigate the production of secondary metabolites. Metabolomic analyses revealed the production of several known compounds, such as sphaeropsidins, diplopyrones and diplofuranones. Moreover, the comparative investigation of secondary metabolites produced by the analyzed strains with different degrees of virulence revealed possible implications of these compounds in the Fungal virulence. In particular, sphaeropsidins seem to be the main phytotoxic compounds of D. corticola involved in the infections of Quercus species, with a possible synergistic influence of the less representative compounds in the Fungal virulence.

Keywords

HPLC-ESI-HRMS; culture filtrates; mycelial extracts; quantitative analysis; sphaeropsidins; virulence factors.

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