2. Academic Validation
  3. MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation

MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation

  • Eur J Med Chem. 2023 Nov 15:260:115781. doi: 10.1016/j.ejmech.2023.115781.
Shuo Li 1,  Jia-Shu Chen 2,  Xiangqian Li 3,  Xiaoyi Bai 4,  Dayong Shi 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, PR China. Electronic address: 202012639@mail.sdu.edu.cn.
  • 2 State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, PR China. Electronic address: sdfzcjs@163.com.
  • 3 State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, PR China. Electronic address: lixiangqian@sdu.edu.cn.
  • 4 State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, PR China. Electronic address: 202112523@mail.sdu.edu.cn.
  • 5 State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, PR China. Electronic address: shidayong@sdu.edu.cn.
PMID: 37669595 DOI: 10.1016/j.ejmech.2023.115781
Abstract

Overexpression of eIF4E is common in patients with various solid tumors and hematologic cancers. As a potential anti-cancer target, eIF4E has attracted extensive attention from researchers. At the same time, mTOR kinases inhibitors and MNK kinases inhibitors, which are directly related to regulation of eIF4E, have been rapidly developed. To explore the optimal anti-cancer targets among MNK, mTOR, and eIF4E, this review provides a detailed classification and description of the anti-cancer activities of promising compounds. In addition, the structures and activities of some dual-target inhibitors are briefly described. By analyzing the different characteristics of the inhibitors, it can be concluded that MNK1/2 and eIF4E/eIF4G interaction inhibitors are superior to mTOR inhibitors. Simultaneous inhibition of MNK and eIF4E/eIF4G interaction may be the most promising anti-cancer method for targeting translation initiation.

Keywords

MNK inhibitor; eIF4E inhibitor; mTOR inhibitor.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-W348485
    mTOR Complex 1 Inhibitor