2. Academic Validation
  3. Vascular Endothelial Growth Factor Mimetic Peptide and Parathyroid Hormone (1-34) Delivered via a Blue-Light-Curable Hydrogel Synergistically Accelerate Bone Regeneration

Vascular Endothelial Growth Factor Mimetic Peptide and Parathyroid Hormone (1-34) Delivered via a Blue-Light-Curable Hydrogel Synergistically Accelerate Bone Regeneration

  • ACS Appl Mater Interfaces. 2022 Aug 10;14(31):35319-35332. doi: 10.1021/acsami.2c06159.
Guiyan Wang 1,  Ning Yuan 2,  Ningyu Li 3,  Qijia Wei 2,  Yuping Qian 4,  Jun Zhang 2,  Man Qin 1,  Yuguang Wang 1,  Suwei Dong 2
Affiliations

Affiliations

  • 1 National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, and Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China.
  • 2 State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, and School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • 3 Department of Oral Comprehensive Treatment, Jilin University School and Hospital of Stomatology, Changchun 130021, China.
  • 4 Department of Prosthodontics, Jilin University School and Hospital of Stomatology, Changchun 130021, China.
PMID: 35881151 DOI: 10.1021/acsami.2c06159
Abstract

Safe and effective biomaterials are in urgent clinical need for tissue regeneration and bone repair. While numerous advances have been made on hydrogels promoting osteogenesis in bone formation, co-stimulation of the angiogenic pathways in this process remains to be exploited. Here, we have developed a gelatin-based blue-light-curable hydrogel system, functionalized with an angiogenic vascular endothelial growth factor (VEGF) mimetic peptide, KLTWQELYQLKYKGI (KLT), and an osteoanabolic peptide, parathyroid hormone (PTH) 1-34. We have discovered that the covalent modification of gelatin scaffold with peptides can modulate the physical properties and biological activities of the produced hydrogels. Furthermore, we have demonstrated that those two peptides orchestrate synergistically and promote bone regeneration in a rat cranial bone defect model with remarkable efficacy. This dual-peptide-functionalized hydrogel system may serve as a promising lead to functional biomaterials in bone repair and tissue engineering.

Keywords

PTH(1−34); VEGF mimetic peptide; blue-light-curable hydrogel; bone regeneration; covalent functionalization.

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