2. Academic Validation
  3. The association between urinary levels of 1,3-butadiene metabolites, cardiovascular risk factors, microparticles, and oxidative stress products in adolescents and young adults

The association between urinary levels of 1,3-butadiene metabolites, cardiovascular risk factors, microparticles, and oxidative stress products in adolescents and young adults

  • J Hazard Mater. 2020 Sep 5:396:122745. doi: 10.1016/j.jhazmat.2020.122745.
Chien-Yu Lin 1,  Hui-Ling Lee 2,  Wei-Ting Jung 2,  Fung-Chang Sung 3,  Ta-Chen Su 4
Affiliations

Affiliations

  • 1 Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan; Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan.
  • 2 Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan.
  • 3 Department of Health Services Administration, College of Public Health, China Medical University, Taichung 404, Taiwan.
  • 4 Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei 100, Taiwan; Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei 100, Taiwan; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, 100, Taiwan. Electronic address: tachensu@ntu.edu.tw.
PMID: 32361133 DOI: 10.1016/j.jhazmat.2020.122745
Abstract

1,3-Butadiene (BD) is a synthetic colorless gas used in the production of synthetic rubber and Polymers. Exposure to BD has been reported to increase oxidative stress and accelerate atherosclerosis in vitro and in animal studies. In occupational studies, BD exposure has been linked to Cardiovascular Disease (CVD). However, no previous research has been reported on whether BD exposure is associated with CVD risk factors and oxidative stress in the general population. We recruited 853 young participants to study the correlation between urinary levels of the BD metabolite, N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA), CVD risk factors, serum levels of endothelial microparticles and platelet microparticles, and the urinary levels of 8-hydroxydeoxyguanosine (8-OHdG). The results showed the DHBMA levels were positively correlated with low-density lipoprotein-C, carotid intima-media thickness (CIMT), CD31+/CD42a - counts (endothelial Apoptosis markers), and urinary 8-OHdG levels. Moreover, DHBMA levels were negatively correlated with CD62 P counts (platelet activation marker). The correlation between DHBMA, CIMT, and 8-OHdG was more evident when the levels of CD31+/CD42a - or CD62 P were above 50%. In conclusion, we reported that the urinary levels of DHBMA were associated with the lipid profile, CIMT, microparticles, and marker of oxidative stress in this young population. Future studies on BD exposure and atherosclerosis are needed.

Keywords

1,3-Butadiene (BD); 8-Hydroxydeoxyguanosine (8-OHdG); Endothelial microparticles (EMPs); N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA); Platelet microparticles (PMPs).

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