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  3. Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19-9 expression occurring in elderly individuals: An autopsy study

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19-9 expression occurring in elderly individuals: An autopsy study

  • Pathol Int. 2020 Feb;70(2):92-100. doi: 10.1111/pin.12882.
Tan Wang 1 2 3,  Yoko Matsuda 2 4,  Keisuke Nonaka 2,  Mototsune Kakizaki 2,  Toshiyuki Ishiwata 3,  Nobuo Kanazawa 5,  Satoko Uegaki 6,  Masaaki Muramatsu 7,  Motoji Sawabe 8,  Seijiro Mori 9,  Masashi Tanaka 10,  Masanobu Kitagawa 1,  Tomio Arai 2
Affiliations

Affiliations

  • 1 Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • 2 Departments of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
  • 3 Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
  • 4 Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • 5 Departments of Surgery, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
  • 6 Departments of Gastroenterology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
  • 7 Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
  • 8 Department of Molecular Pathology, Graduate School of Health Care Science, Tokyo Medical and Dental University, Tokyo, Japan.
  • 9 Departments of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
  • 10 Department of Laboratory Medicine, IMS Miyoshi General Hospital, Saitama, Japan.
PMID: 31867815 DOI: 10.1111/pin.12882
Abstract

The clinicopathological significance of carbohydrate antigen 19-9 (CA19-9) in gastric Cancer (GC) remains obscure. Therefore, the current study aimed to clarify the clinicopathological value of CA19-9 in GC utilizing autopsy cases. We examined the expression of CA19-9 and Mucin core proteins in GC immunohistochemically, and analyzed serum CA19-9 levels and clinicopathological variables or complications. We also investigated whether fucosyltransferases 2 and 3 (FUT2/3) allelic variants influence CA19-9 expression in GC. Compared to GC cases with negative CA19-9 expression (tCA19-9-N), those with positive CA19-9 expression (tCA19-9-P) demonstrated significant differences in characteristic features such as lymph node and distant organ metastases, lymphatic and venous permeation, and higher Tumor, Node, Metastasis (TNM) stages. Moreover, compared to GC cases with low serum CA19-9 levels (sCA19-9-L), those with high serum CA19-9 levels (sCA19-9-H) were related to venous permeation, higher proportion of lymph node and distant organ metastases, and higher TNM stages. Both tCA19-9-P GC and sCA19-9-H GC cases were significantly associated with coagulation abnormalities. sCA19-9-H GC cases correlated significantly with MUC1 and MUC5AC expression. FUT2/3 genotypes were not associated with CA19-9 expression in GC. These results suggest that CA19-9 can predict the risk of lymph node and distant metastases as well as of coagulation abnormalities.

Keywords

autopsy; carbohydrate antigen 19-9; coagulation abnormalities; elderly; gastric cancer; immunohistochemistry.

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