2. Academic Validation
  3. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301

Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301

  • Fitoterapia. 2019 Jun:135:27-32. doi: 10.1016/j.fitote.2019.03.031.
Nianzhen Liu 1,  Shuai Peng 1,  Jie Yang 2,  Ziwen Cong 3,  Xiuping Lin 3,  Shengrong Liao 3,  Bin Yang 3,  Xuefeng Zhou 3,  Xiaojiang Zhou 4,  Yonghong Liu 5,  Junfeng Wang 6
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine MateriaMedica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
  • 2 Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for EmergingVirusPrevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • 3 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine MateriaMedica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
  • 4 College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China. Electronic address: gale9888@163.com.
  • 5 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine MateriaMedica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: yonghongliu@scsio.ac.cn.
  • 6 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine MateriaMedica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. Electronic address: wangjunfeng@scsio.ac.cn.
PMID: 30946944 DOI: 10.1016/j.fitote.2019.03.031
Abstract

Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new Xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the Sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their Antiviral, cytotoxic, and Antibacterial activities. Among them, new compounds 2 and 3 displayed obvious selective inhibitory activities against two influenza A virus subtypes, including A/Puerto Rico/8/34 (H1N1) and A/FM-1/1/47 (H1N1), with IC50 values ranging from 2.17 ± 1.39 to 4.70 ± 1.11 μM.

Keywords

Antiviral activity; Aspergillus sydowii; Sesquiterpenoid; Xanthone.

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