2. Academic Validation
  3. The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease

The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease

  • Front Immunol. 2019 Mar 19:10:464. doi: 10.3389/fimmu.2019.00464.
Jessica C Anania 1 2,  Alicia M Chenoweth 1 2,  Bruce D Wines 1 2 3,  P Mark Hogarth 1 2 3
Affiliations

Affiliations

  • 1 Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia.
  • 2 Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
  • 3 Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia.
PMID: 30941127 DOI: 10.3389/fimmu.2019.00464
Abstract

FcγRs have been the focus of extensive research due to their key role linking innate and humoral immunity and their implication in both inflammatory and infectious disease. Within the human FcγR family FcγRII (activatory FcγRIIa and FcγRIIc, and inhibitory FcγRIIb) are unique in their ability to signal independent of the common γ chain. Through improved understanding of the structure of these receptors and how this affects their function we may be able to better understand how to target FcγR specific immune activation or inhibition, which will facilitate in the development of therapeutic monoclonal antibodies in patients where FcγRII activity may be desirable for efficacy. This review is focused on roles of the human FcγRII family members and their link to immunoregulation in healthy individuals and Infection, autoimmunity and Cancer.

Keywords

Fc receptor; FcγR; autoimmunity; cancer; infection; inflammation; mAb therapeutics.

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