2. Academic Validation
  3. Expanding the tetrahydroquinoline pharmacophore

Expanding the tetrahydroquinoline pharmacophore

  • Bioorg Med Chem Lett. 2017 Apr 15;27(8):1714-1720. doi: 10.1016/j.bmcl.2017.02.077.
Navya Goli 1,  Prathama S Mainkar 2,  Sudha Sravanti Kotapalli 3,  Tejaswini K 3,  Ramesh Ummanni 4,  Srivari Chandrasekhar 5
Affiliations

Affiliations

  • 1 Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi, India.
  • 2 Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • 3 Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • 4 Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi, India.
  • 5 Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi, India. Electronic address: srivaric@iict.res.in.
PMID: 28318941 DOI: 10.1016/j.bmcl.2017.02.077
Abstract

Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquinoline as neurotropic agents not reported earlier.

Keywords

Neurotropic agents; Povarov reaction; Tetrahydroquinoline.

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