2. Academic Validation
  3. Diffuse idiopathic skeletal hyperostosis: A review

Diffuse idiopathic skeletal hyperostosis: A review

  • Surg Neurol Int. 2014 Apr 16;5(Suppl 3):S122-5. doi: 10.4103/2152-7806.130675.
Fábio A Nascimento 1,  Luana Antunes Maranha Gatto 2,  Roberto Oliver Lages 3,  Heraldo Mello Neto 4,  Zeferino Demartini 5,  Gelson Luis Koppe 6
Affiliations

Affiliations

  • 1 Faculty of Medicine, Universidade Federal do Paraná, Brazil.
  • 2 Department of Neurosurgery of Hospital Universitário Cajuru, Curitiba, Paraná, Neurosurgeon, Fellow of Interventional Neuroradiology, Neurosurgery Resident, Curitiba, Paraná, Brazil.
  • 3 Department of Neurosurgery of Hospital Universitário Cajuru, Curitiba, Paraná, Brazil.
  • 4 Radiologist in Clínica X Leme, Curitiba, Paraná, Brazil.
  • 5 Department of Neurosurgery of Hospital Universitário Cajuru, Curitiba, Paraná, Neurosurgeon and Interventional Neuroradiologist, Curitiba, Paraná Brazil.
  • 6 Department of Neurosurgery of Hospital Universitário Cajuru, Curitiba, Paraná, Interventional Neuroradiologist in Hospital Universitário Cajuru, Curitiba, Paraná, Brazil.
PMID: 24843807 DOI: 10.4103/2152-7806.130675
Abstract

Background: Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic noninflammatory disease characterized by ossification of the entheses.

Methods: This paper reviews the etiopathogenesis, epidemiology, clinical features, differential diagnosis, and treatment of DISH, based on current available literature.

Results: Exact prevalence and incidence of DISH remains undetermined. Many external and genetic factors have been reported as being contributors to the pathogenesis of DISH. Current theories focus on the pathologic calcification of the anterior longitudinal ligament of the spine as the main physiopathological mechanism of disease. Clinical features are variable from monoarticular sinovitis to airway obstruction, and can be associated to systemic conditions. Comorbidities include obesity, hypertension, diabetes mellitus, hyperinsulinemia, dyslipidemia, and hyperuricemia according to a number of reports.

Conclusions: DISH is a disease which involves the calcification of the anterior longitudinal ligament of the spine and can be associated with numerous clinical presentations and comorbidities.

Keywords

Anterior Longitudinal Ligament; Forestier's disease; diffuse idiopathic skeletal hyperostosis.

Figures