2. Academic Validation
  3. Synthesis of the griseusin B framework via a one-pot annulation-methylation-double deprotection-spirocyclization sequence

Synthesis of the griseusin B framework via a one-pot annulation-methylation-double deprotection-spirocyclization sequence

  • Org Lett. 2013 Apr 19;15(8):2006-9. doi: 10.1021/ol400686f.
Briar J Naysmith 1,  Margaret A Brimble
Affiliations

Affiliation

  • 1 School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
PMID: 23560611 DOI: 10.1021/ol400686f
Abstract

A highly convergent synthesis of the griseusin B scaffold is described. The key step involves an efficient one-pot Hauser-Kraus annulation-methylation-double deprotection-spirocyclization sequence that directly affords the target parent tetracyclic ring system.

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