2. Academic Validation
  3. Interleukin-13 signaling and its role in asthma

Interleukin-13 signaling and its role in asthma

  • World Allergy Organ J. 2011 Mar;4(3):54-64. doi: 10.1097/WOX.0b013e31821188e0.
Efren L Rael 1,  Richard F Lockey
Affiliations

Affiliation

  • 1 From the 1Department of Allergy, Asthma and Immunology, Penn State Hershey Medical Center MCH0401, Hershey, PA; 2University Distinguished Health Professor, Professor of Medicine, Pediatrics & Public Health; Director, Division of Allergy & Immunology, Joy McCann Culverhouse Chair in Allergy & Immunology; World Allergy Organization President; University of South Florida College of Medicine University of South Florida; James A. Haley Veterans' Hospital, Department of A/I (111D), Tampa, FL.
PMID: 23283176 DOI: 10.1097/WOX.0b013e31821188e0
Abstract

Asthma affects nearly 300 million people worldwide. The majority respond to inhaled corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to 10% with severe asthma do not respond optimally to these medications. Different phenotypes of asthma may explain why current therapies show limited benefits in subgroups of patients. Interleukin-13 is implicated as a central regulator in IgE synthesis, mucus hypersecretion, airway hyperresponsiveness, and fibrosis. Promising research suggests that the interleukin-13 pathway may be an important target in the treatment of the different asthma phenotypes.

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