2. Academic Validation
  3. Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)

Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)

  • Bioorg Med Chem Lett. 2009 Aug 1;19(15):4059-63. doi: 10.1016/j.bmcl.2009.06.021.
Scott D Kuduk 1,  Ronald K Chang,  Jenny M-C Wai,  Christina N Di Marco,  Victoria Cofre,  Robert M DiPardo,  Sean P Cook,  Matthew J Cato,  Aneta Jovanovska,  Mark O Urban,  Michael Leitl,  Robert H Spencer,  Stefanie A Kane,  George D Hartman,  Mark T Bilodeau
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. scott_d_kuduk@merck.com
PMID: 19553111 DOI: 10.1016/j.bmcl.2009.06.021
Abstract

A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.

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