2. Academic Validation
  3. 1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis

1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis

  • Cancer Lett. 2009 Jun 8;278(1):34-40. doi: 10.1016/j.canlet.2008.12.020.
Tomoko Kayashima 1,  Masaharu Mori,  Hiromi Yoshida,  Yoshiyuki Mizushina,  Kiminori Matsubara
Affiliations

Affiliation

  • 1 Department of Human Life Science Education, Graduate School of Education, Hiroshima University, 111 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8524, Japan.
PMID: 19168278 DOI: 10.1016/j.canlet.2008.12.020
Abstract

Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis-dependent diseases including Cancer. Vitamin K2 and K3, which are naphthoquinone derivatives, inhibit angiogenesis. We examined the anti-cancer and anti-angiogenic effects of naphthoquinones and its structurally related compounds. Among these 13 compounds, 1,4-naphthoquinone strongly inhibited both human colon Cancer cell (HCT116) growth and angiogenesis. To clarify the anti-angiogenic mechanism, the effects of 1,4-naphthoquinone on human umbilical vein endothelial cell (HUVEC) tube formation, proliferation and chemotaxis were examined. Consequently, 1,4-naphthoquinone inhibited HUVEC functions. These results suggest that 1,4-naphthoquinone may be useful to Cancer therapy.

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