A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size

Nat Genet. 2005 Apr;37(4):353-5. doi: 10.1038/ng1539.

Jacquelyn Bond ¹, Emma Roberts, Kelly Springell, Sofia B Lizarraga, Sheila Scott, Julie Higgins, Daniel J Hampshire, Ewan E Morrison, Gabriella F Leal, Elias O Silva, Suzana M R Costa, Diana Baralle, Michela Raponi, Gulshan Karbani, Yasmin Rashid, Hussain Jafri, Christopher Bennett, Peter Corry, Christopher A Walsh, C Geoffrey Woods

Affiliations

Affiliation

1 Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

PMID: 15793586 DOI: 10.1038/ng1539

Abstract

Autosomal recessive primary microcephaly is a potential model in which to research genes involved in human brain growth. We show that two forms of the disorder result from homozygous mutations in the genes CDK5RAP2 and CENPJ. We found neuroepithelial expression of the genes during prenatal neurogenesis and protein localization to the spindle poles of mitotic cells, suggesting that a centrosomal mechanism controls neuron number in the developing mammalian brain.

Name
Email *

	Sorry, but the email address you supplied was invalid.