2. Academic Validation
  3. Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety

  • Bioorg Med Chem Lett. 2003 Jun 16;13(12):2059-63. doi: 10.1016/s0960-894x(03)00258-0.
Edwin J Iwanowicz 1,  Scott H Watterson,  Junqing Guo,  William J Pitts,  T G Murali Dhar,  Zhongqi Shen,  Ping Chen,  Henry H Gu,  Catherine A Fleener,  Katherine A Rouleau,  Daniel L Cheney,  Robert M Townsend,  Diane L Hollenbaugh
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. iwanowie@bms.com
PMID: 12781195 DOI: 10.1016/s0960-894x(03)00258-0
Abstract

The first reported structure-activity relationships (SARs) about the N-[3-methoxy-4-(5-oxazolyl)phenyl moiety for a series of recently disclosed inosine monophosphate dehydrogenase (IMPDH) inhibitors are described. The syntheses and in vitro inhibitory values for IMPDH II, and T-cell proliferation (for select analogues) are given.

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