2. Academic Validation
  3. Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis

Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis

  • Bioorg Med Chem Lett. 2002 Oct 7;12(19):2785-8. doi: 10.1016/s0960-894x(02)00528-0.
Youichi Shinozaki 1,  Narihiko Fukamiya,  Chieko Uchiyama,  Masayoshi Okano,  Kiyoshi Tagahara,  Kenneth F Bastow,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
PMID: 12217376 DOI: 10.1016/s0960-894x(02)00528-0
Abstract

Twelve taxane diterpenes (1-12), which were isolated previously from the EtOH extract of the aerial parts of Taxus yunnanensis or Taxus chinensis, were evaluated for cytotoxicity against the multidrug resistant Cancer cells KB-VIN and KB-7d. Compounds and showed significant cytotoxicity in these cell lines. Compounds and also demonstrated significant activity against KB-7d. The biflavonoid isolated from T. yunnanensis was only marginally cytotoxic against the A549 (lung) cell line, but a simple methoxylated analogue (14) was inactive.

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