2. Academic Validation
  3. Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

  • J Nat Prod. 2000 Jun;63(6):753-6. doi: 10.1021/np990478k.
J S Lee 1,  J Kim,  B Y Kim,  H S Lee,  J S Ahn,  Y S Chang
Affiliations

Affiliation

  • 1 College of Pharmacy, Seoul National University, Seoul 151-742, Korea, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
PMID: 10869194 DOI: 10.1021/np990478k
Abstract

Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six Phospholipase Cgamma1 (PLCgamma1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCgamma1 in vitro with IC(50) values of 9.5-44.6 microM and inhibited the proliferation of human Cancer cells with IC(50) values of 0.5-6.5 microg/mL.

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