2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. LY5

LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer.

For research use only. We do not sell to patients.

LY5

LY5 Chemical Structure

CAS No. : 1436382-03-4

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Based on 1 publication(s) in Google Scholar

LY5 Related Antibodies

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Description

LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer[1].

IC50 & Target

IC50: 0.5 μM (STAT3)[1]
Cellular Effect
Cell Line Type Value Description References
SJRH30 IC50
0.55 μM
Compound: 8, LY5
Cytotoxicity against human Rh30 cells assessed as cell viability by MTT assay
Cytotoxicity against human Rh30 cells assessed as cell viability by MTT assay
[PMID: 23651330]
U2OS IC50
0.5 μM
Compound: 8, LY5
Cytotoxicity against human U2OS cells assessed as cell viability by MTT assay
Cytotoxicity against human U2OS cells assessed as cell viability by MTT assay
[PMID: 23651330]
In Vitro

LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC50 values of 0.52, 0.55 and 1.39 μM, respectively[1].
LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells[1].
LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY5 Related Antibodies

Western Blot Analysis[1]

Cell Line: RH30 and EW8 cell lines
Concentration: 0.25-1 μM
Incubation Time: 16 hours
Result: Completely inhibited Tyr705 phosphorylation at 0.5 μM and dose-dependently decreased in formation of P-STAT3.
In Vivo

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with MDA-MB-231 cancer cells injection[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result: Suppressed tumor growth and significantly reduced the tumor sizes.
Molecular Weight

329.33

Formula

C15H11N3O4S
CAS No.
Appearance

Solid

Color

Brown to red

SMILES

NS(=O)(C1=C2C(C(C(NC3=CC=CN=C3)=CC2=O)=O)=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.25 mg/mL (18.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0365 mL 15.1823 mL 30.3647 mL
5 mM 0.6073 mL 3.0365 mL 6.0729 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0365 mL 15.1823 mL 30.3647 mL 75.9117 mL
5 mM 0.6073 mL 3.0365 mL 6.0729 mL 15.1823 mL
10 mM 0.3036 mL 1.5182 mL 3.0365 mL 7.5912 mL
15 mM 0.2024 mL 1.0122 mL 2.0243 mL 5.0608 mL
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LY5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY51436382-03-4LY 5LY-5STATApoptosisapoptosisphosphorylationantitumorcancerU2OSRH30RD2IL-6miceInhibitorinhibitorinhibit

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