2. MAPK/ERK Pathway PI3K/Akt/mTOR
  3. MEK mTOR
  4. LP-65

LP-65 is a dual inhibitor of MEK (IC50=83.2 nM) and mTOR (IC50=40.5 nM). LP-65 blocks MEK and mTOR signaling pathways and inhibits tumor cell proliferation and migration. LP-65 is promising for research of cancers.

For research use only. We do not sell to patients.

LP-65 Chemical Structure

LP-65 Chemical Structure

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LP-65 Related Antibodies

Top Publications Citing Use of Products

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MEK1 MEK2 MEK5 MEK

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mTOR mTORC1 mTORC2

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Description

LP-65 is a dual inhibitor of MEK (IC50=83.2 nM) and mTOR (IC50=40.5 nM). LP-65 blocks MEK and mTOR signaling pathways and inhibits tumor cell proliferation and migration. LP-65 is promising for research of cancers[1].

Molecular Weight

1059.86

Formula

C47H53F3IN7O10
SMILES

FC1=C(F)C(NC2=C(F)C=C(I)C=C2)=C(C(NOCCOCCOCCOCCC(OCC3=CC(C4=CC=C(C(N5CCOC[C@@H]5C)=NC(N6CCOC[C@@H]6C)=N7)C7=N4)=CC=C3OC)=O)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LP-65 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LP-65LP65LP 65MEKmTORMitogen-activated protein kinase kinaseMAPKKMAP2KMammalian target of Rapamycintumor cellInhibitorinhibitorinhibit

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