2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3 β-catenin Wnt
  4. GSK3β-IN-2

GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model.

For research use only. We do not sell to patients.

GSK3β-IN-2 Chemical Structure

GSK3β-IN-2 Chemical Structure

CAS No. : 3068378-38-8

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GSK3β-IN-2 Related Antibodies

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Description

GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model[1].

IC50 & Target

GSK3β

0.35 nM (IC50)

Molecular Weight

390.44

Formula

C25H18N4O
CAS No.
SMILES

O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=CC=C5)C=CN=C4
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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GSK3β-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3β-IN-23068378-38-8GSK-3β-cateninWntGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninADAlzheimer's DiseaseSH-SY5YzebrafishInhibitorinhibitorinhibit

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