GSK3β-IN-2

Cat. No.: HY-172171 Purity: 98.75%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC₅₀ of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model.

For research use only. We do not sell to patients.

GSK3β-IN-2 Chemical Structure

CAS No. : 3068378-38-8

Size		Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution		Check price and availability
Solution
10 mM * 1 mL in DMSO		Check price and availability
Solid
5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability
50 mg		Check price and availability
100 mg		Check price and availability

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

GSK3β

0.35 nM (IC₅₀)

Molecular Weight

390.44

Formula

C₂₅H₁₈N₄O

CAS No.

3068378-38-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=CC=C5)C=CN=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (256.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5612 mL	12.8061 mL	25.6121 mL
5 mM	0.5122 mL	2.5612 mL	5.1224 mL
10 mM	0.2561 mL	1.2806 mL	2.5612 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.75%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (254 KB) HNMR (285 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Xun QQ, et al., Identification of a novel pyrrolo[2,3-b]pyridine compound as a potent glycogen synthase kinase 3β inhibitor for treating Alzheimer's disease. J Enzyme Inhib Med Chem. 2025 Dec;40(1):2466846. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5612 mL	12.8061 mL	25.6121 mL	64.0303 mL
	5 mM	0.5122 mL	2.5612 mL	5.1224 mL	12.8061 mL
	10 mM	0.2561 mL	1.2806 mL	2.5612 mL	6.4030 mL
	15 mM	0.1707 mL	0.8537 mL	1.7075 mL	4.2687 mL
	20 mM	0.1281 mL	0.6403 mL	1.2806 mL	3.2015 mL
	25 mM	0.1024 mL	0.5122 mL	1.0245 mL	2.5612 mL
	30 mM	0.0854 mL	0.4269 mL	0.8537 mL	2.1343 mL
	40 mM	0.0640 mL	0.3202 mL	0.6403 mL	1.6008 mL
	50 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.2806 mL
	60 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0672 mL
	80 mM	0.0320 mL	0.1601 mL	0.3202 mL	0.8004 mL
	100 mM	0.0256 mL	0.1281 mL	0.2561 mL	0.6403 mL

GSK3β-IN-2 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3β-IN-23068378-38-8GSK-3β-cateninWntGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninADAlzheimer's DiseaseSH-SY5YzebrafishInhibitorinhibitorinhibit

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