2. Gene
  3. Hadha - hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Gene

Hadha - hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mtpa; TP-alpha

Gene ID: 97212 | Gene type: protein coding

About Hadha

Summary

Enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Acts upstream of or within fatty acid beta-oxidation and response to Insulin. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hadha Products(1)

mRNA Protein Name
NM_178878.3 NP_849209.1 trifunctional enzyme subunit alpha, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IDA
IDA: Inferred from direct assay
15240869 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29949755 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
11390422 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
15887119 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

trifunctional enzyme subunit alpha, mitochondrial

hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

monolysocardiolipin acyltransferase

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0968A Trimetazidine Inducer 99.84% Yes
HY-B0968 Trimetazidine dihydrochloride Inducer 99.91% Yes
HY-B0968R Trimetazidine (dihydrochloride) (Standard) Inducer 99.94% Unkown
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0968S Trimetazidine-d8 dihydrochloride Inducer 99.87 Unkown
HY-RS05990 HADHA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-B0968S1 Trimetazidine-d9 dihydrochloride Inducer / Unkown
HY-RS17506 Hadha Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23963 Hadha Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hadha NCBI NCBI:3030