Socs3 - suppressor of cytokine signaling 3 Gene

Rattus norvegicus

Also known as Cish3; Ssi-3; Socs-3

Gene ID: 89829 | Gene type: protein coding

About Socs3

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity and phosphotyrosine residue binding activity. Involved in several processes, including receptor signaling pathway via JAK-STAT; response to estradiol; and response to steroid hormone. Located in cytoplasm. Biomarker of obesity; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Apr 2022]

Socs3 Products(1)

mRNA	Protein	Name
NM_053565.1	NP_446017.1	suppressor of cytokine signaling 3

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	11867182	RGD
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	12239110	RGD
involved in cellular response to thyrotropin-releasing hormone	IEP IEP: Inferred from expression pattern	10707961	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	10707961	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12239110	RGD
involved in response to bacterium	IEP IEP: Inferred from expression pattern	17405912	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	18424750	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18325991	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	12163036	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	14751512	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	10998044	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	11133009	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16125475	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	15192048	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18424750	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12239110	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	12107179	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	18325991	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17394460	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

suppressor of cytokine signaling 3

cytokine inducible SH2-containing protein 3

cytokine-inducible SH2 protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155335	FPR2 agonist 3	Agonist	99.39%	Unkown
HY-117511	HJC0123		/	Unkown
HY-169908	STAT3-IN-37	Inhibitor	/	Unkown
HY-172402	Vasoactive intestinal peptide		/	Unkown
HY-RS13554	SOCS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16260	Socs3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23359	Socs3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990001	Anti-Mouse IL-10 Antibody (JES5-2A5)	Inhibitor	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Socs3	NCBI	NCBI:9021

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