Angpt2 - angiopoietin 2 Gene

Rattus norvegicus

Also known as Agpt2; Ang-2

Gene ID: 89805 | Gene type: protein coding

About Angpt2

Summary

Predicted to enable receptor tyrosine kinase binding activity. Involved in several processes, including blood vessel development; maternal process involved in female pregnancy; and positive regulation of angiogenesis. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study several diseases, including ischemia (multiple); membranoproliferative glomerulonephritis; portal hypertension; retinal disease (multiple); and uremia. Biomarker of several diseases, including Caroli disease; artery disease (multiple); glomerulonephritis (multiple); musculoskeletal system Cancer (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2). [provided by Alliance of Genome Resources, Apr 2022]

Angpt2 Products(1)

mRNA	Protein	Name
NM_134454.1	NP_604449.1	angiopoietin-2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	16439712	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	16437624	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	16176970	RGD
involved in germ cell development	IEP IEP: Inferred from expression pattern	18996974	RGD
involved in glomerulus vasculature development	IMP IMP: Inferred from mutant phenotype	20056745	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	16452728	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	15542434	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	18342145	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	15048134	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	17943991	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19012730	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19672036	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	18272601	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16628643	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiopoietin-2

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990689	Zifibancimig		99.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00688	ANGPT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16719	Angpt2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23155	Angpt2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Angpt2	NCBI	NCBI:285
Canis familiaris	Angpt2	NCBI	NCBI:607616
Macaca fascicularis	Angpt2	NCBI	NCBI:101925495
Canis lupus familiaris	Angpt2	NCBI
Mus musculus	Angpt2	NCBI	NCBI:11601
Macaca mulatta	Angpt2	NCBI	NCBI:716811

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