Rag1 - recombination activating 1 Gene

About Rag1

Summary

Predicted to enable several functions, including protein homodimerization activity; ubiquitin protein Ligase activity; and zinc ion binding activity. Predicted to contribute to double-stranded DNA endodeoxyribonuclease activity. Involved in regulation of behavioral fear response and visual learning. Predicted to be part of DNA recombinase complex and endodeoxyribonuclease complex. Predicted to be active in nucleus. Used to study hypertension and severe combined immunodeficiency. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG1 (recombination activating 1). [provided by Alliance of Genome Resources, Apr 2022]