Ralbp1 - ralA binding protein 1 Gene

Rattus norvegicus

Also known as RIP1; RLIP76

Gene ID: 84014 | Gene type: protein coding

About Ralbp1

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including mitotic spindle organization; negative regulation of smooth muscle cell proliferation; and regulation of intracellular signal transduction. Located in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ralbp1 Products(2)

mRNA	Protein	Name
NM_001393664.1	NP_001380593.1	ralA-binding protein 1
NM_032067.2	NP_114456.2	ralA-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	7623849	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21242975	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	7623849	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	19823667	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16648138	RGD
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23788031	RGD
involved in regulation of Cdc42 protein signal transduction	IDA IDA: Inferred from direct assay	7623849	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP EXP: Inferred from Experiment	19823667	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	19823667	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	19823667	RGD
involved in small GTPase-mediated signal transduction	IPI IPI: Inferred from physical interaction	7623849	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	19823667	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	19823667	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	19823667	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ralA-binding protein 1

DNP-SG ATPase	cytocentrin
dinitrophenyl S-glutathione ATPase	ral-interacting protein 1

Ralbp1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ralbp1	Q62796	CCND1	Homo sapiens	P24385	Pull Down	21242975

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125987	RBC6	Inhibitor	98.88%	Unkown
HY-123464	RBC10	Inhibitor	≥98.0%	Unkown
HY-RS11629	RALBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11845	REPS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18714	Ralbp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25201	Ralbp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ralbp1	NCBI	NCBI:10928

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