Phip - pleckstrin homology domain interacting protein Gene

Mus musculus

Also known as Ndrp; Wdr11; 2810004D21Rik; 4632404O06Rik

Gene ID: 83946 | Gene type: protein coding

About Phip

Summary

Predicted to enable lysine-acetylated histone binding activity. Involved in several processes, including positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of mitotic nuclear division; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including Insulin Receptor signaling pathway; positive regulation of protein phosphorylation; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; female reproductive system; retina; and urinary system. Orthologous to human PHIP (pleckstrin homology domain interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Phip Products(1)

mRNA	Protein	Name
NM_001081216.1	NP_001074685.1	PH-interacting protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11018022	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	20816727	MGI
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	11018022	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	17636024	MGI
acts upstream of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17636024	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17636024	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17636024	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	20816727	MGI
involved in positive regulation of insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	17636024	MGI
involved in positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	17636024	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17636024	MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	17636024	MGI
acts upstream of or within positive regulation of type B pancreatic cell proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20816727	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	20816727	MGI
involved in regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	17636024	MGI
acts upstream of type B pancreatic cell proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17636024	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

PH-interacting protein

IRS-1 PH domain-binding protein	WD repeat domain 11
WD repeat-containing protein 11	neuronal differentiation-related protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-118716	PhIP		99.93%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118716S	PhIP-d3		/	Unkown
HY-RS10436	PHIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21408	Phip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27927	Phip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Phip	NCBI	NCBI:55023

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