Pax8 - paired box 8 Gene

Rattus norvegicus

Gene ID: 81819 | Gene type: protein coding

About Pax8

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated and sulfur compound metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8). [provided by Alliance of Genome Resources, Apr 2022]

Pax8 Products(1)

mRNA	Protein	Name
NM_031141.2	NP_112403.2	paired box protein Pax-8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15888455	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1508216	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1508216	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12441357	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11145590	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9214635	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1508216	RGD
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11145590	RGD
involved in sulfur compound metabolic process	IEP IEP: Inferred from expression pattern	12237116	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	12441357	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paired box protein Pax-8

Pax-8 protein

paired box gene 8

Pax8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pax8	P51974	Nkx2-1	Rattus norvegicus	P23441	Pull Down	12441357
Intra	Pax8	P51974	Wbp2	Rattus norvegicus	Q8R478	Phage Display	14531730
Intra	Pax8	P51974	Wbp2	Rattus norvegicus	Q8R478	Pull Down	14531730

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10095	PAX8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18962	Pax8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25453	Pax8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax8	NCBI	NCBI:7849

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