Adcy2 - adenylate cyclase 2 Gene

Rattus norvegicus

Also known as AC2

Gene ID: 81636 | Gene type: protein coding

About Adcy2

Summary

Enables several functions, including G-protein beta/gamma-subunit complex binding activity; Adenylate Cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Located in membrane raft and plasma membrane. Is integral component of plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (Adenylate Cyclase 2). [provided by Alliance of Genome Resources, Apr 2022]

Adcy2 Products(1)

mRNA	Protein	Name
NM_031007.3	NP_112269.2	adenylate cyclase type 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein beta/gamma-subunit complex binding	IPI IPI: Inferred from physical interaction	16967511	RGD
enables adenylate cyclase activity	IDA IDA: Inferred from direct assay	1719547	RGD
enables adenylate cyclase binding	IDA IDA: Inferred from direct assay	18164588	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10427002	RGD
enables manganese ion binding	IDA IDA: Inferred from direct assay	10427002	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18772391	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	7761832	RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18164588	RGD
involved in cAMP biosynthetic process	IDA IDA: Inferred from direct assay	10427002	RGD
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	7761832	RGD
involved in cellular response to forskolin	IDA IDA: Inferred from direct assay	1719547	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	18164588	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	18164588	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	7761832	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16967511	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adenylate cyclase type 2

ATP pyrophosphate-lyase 2	adenylate cyclase 2 (brain)
adenylate cyclase type II	adenylyl cyclase 2

Adcy2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Adcy2	P26769	AKAP9	Homo sapiens	Q99996-4	Pull Down	18772391
Cross	Adcy2	P26769	PDE4D	Homo sapiens	Q08499-2	Anti Bait CoIP	20664520
Cross	Adcy2	P26769	PDE4D	Homo sapiens	Q08499-2	Anti Tag CoIP	20664520

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00328	ADCY2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21474	Adcy2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27992	Adcy2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcy2	NCBI	NCBI:108

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