Abi1 - abl-interactor 1 Gene

Rattus norvegicus

Also known as E3b1

Gene ID: 79249 | Gene type: protein coding

About Abi1

Summary

Predicted to enable SH3 domain binding activity; protein tyrosine kinase activator activity; and signaling adaptor activity. Involved in postsynapse to nucleus signaling pathway. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Apr 2022]

Abi1 Products(1)

mRNA	Protein	Name
NM_024397.2	NP_077373.2	abl interactor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17304222	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in postsynapse to nucleus signaling pathway	EXP EXP: Inferred from Experiment	17304222	RGD
involved in postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	17304222	RGD
involved in postsynapse to nucleus signaling pathway	IEP IEP: Inferred from expression pattern	17304222	RGD
involved in postsynapse to nucleus signaling pathway	IMP IMP: Inferred from mutant phenotype	17304222	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17304222	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17304222	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17304222	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	17304222	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	25293574	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

abl interactor 1

abelson interactor 1	abi-1
eps8 SH3 domain-binding protein	eps8 binding protein (e3B1), alternatively spliced
eps8-binding protein

Abi1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Abi1	Q9QZM5	Shank3	Rattus norvegicus	Q9JLU4	Y2H	17304222
Intra	Abi1	Q9QZM5	Shank3	Rattus norvegicus	Q9JLU4	Pull Down	17304222

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00098	ABI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19872	Abi1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26371	Abi1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abi1	NCBI	NCBI:10006

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