Nol3 - nucleolar protein 3 (apoptosis repressor with CARD domain) Gene

Mus musculus

Also known as ARC; MYC; NOP; Nop30; B430311C09Rik

Gene ID: 78688 | Gene type: protein coding

About Nol3

Summary

Enables death effector domain binding activity and death receptor binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; negative regulation of cell death; and regulation of signal transduction. Acts upstream of or within regulation of gene expression; response to hypoxia; and response to injury involved in regulation of muscle adaptation. Located in mitochondrion and sarcoplasm. Is expressed in adrenal gland; brain; lung; metanephros; and musculature. Orthologous to human NOL3 (nucleolar protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Nol3 Products(1)

mRNA	Protein	Name
NM_030152.4	NP_084428.1	nucleolar protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables death effector domain binding	IPI IPI: Inferred from physical interaction	15383280	MGI
enables death receptor binding	IPI IPI: Inferred from physical interaction	24440909	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15383280	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15383280	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	22082675	MGI
involved in cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16505176	MGI
involved in intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	24312627	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22082675	MGI
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16505176	MGI
involved in negative regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	24312627	MGI
involved in negative regulation of muscle atrophy	IMP IMP: Inferred from mutant phenotype	24312627	MGI
involved in negative regulation of programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	24440909	MGI
involved in negative regulation of striated muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24312627	MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24440909	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18782777	MGI
involved in regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	24440909	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	18782777	MGI
acts upstream of or within response to injury involved in regulation of muscle adaptation	IMP IMP: Inferred from mutant phenotype	18782777	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	16505176	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	14645204	MGI
located in sarcoplasm	IDA IDA: Inferred from direct assay	14645204	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleolar protein 3

apoptosis repressor with CARD

Nol3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nol3	Q9D1X0	Tra2a	Mus musculus	Q6PFR5	Pull Down	16249178
Intra	Nol3	Q9D1X0	Tra2a	Mus musculus	Q6PFR5	Y2H	16249178

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09414	NOL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18487	Nol3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24969	Nol3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nol3	NCBI	NCBI:8996

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