Atg16l1 - autophagy related 16-like 1 (S. cerevisiae) Gene

Mus musculus

Also known as WDR30; Apg16l; Atg16l; 1500009K01Rik

Gene ID: 77040 | Gene type: protein coding

About Atg16l1

Summary

Enables identical protein binding activity. Involved in positive regulation of Autophagy. Acts upstream of or within macroautophagy and negative stranded viral RNA replication. Located in autophagosome membrane and axoneme. Is expressed in central nervous system and retina. Used to study inflammatory bowel disease 10. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to human ATG16L1 (Autophagy related 16 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Atg16l1 Products(3)

mRNA	Protein	Name
NM_001205391.1	NP_001192320.1	autophagy-related protein 16-1 isoform 1
NM_001205392.1	NP_001192321.1	autophagy-related protein 16-1 isoform 3
NM_029846.4	NP_084122.2	autophagy-related protein 16-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12665549	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12665549	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	11266458	MGI
involved in axonal transport	IDA IDA: Inferred from direct assay	32210230	MGI
involved in axonal transport	IEP IEP: Inferred from expression pattern	32210230	MGI
involved in axonal transport	IMP IMP: Inferred from mutant phenotype	32210230	MGI
acts upstream of or within corpus callosum development	IMP IMP: Inferred from mutant phenotype	29078390	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	33586810	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	29078390	MGI
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	11266458	MGI
involved in microautophagy	IMP IMP: Inferred from mutant phenotype	33586810	MGI
acts upstream of or within negative stranded viral RNA replication	IMP IMP: Inferred from mutant phenotype	24550300	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	30208760	MGI
acts upstream of or within protein lipidation involved in autophagosome assembly	IDA IDA: Inferred from direct assay	24954904	MGI
acts upstream of or within protein localization to phagophore assembly site	IPI IPI: Inferred from physical interaction	24954904	MGI
acts upstream of or within xenophagy	IPI IPI: Inferred from physical interaction	24954904	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Atg12-Atg5-Atg16 complex	IDA IDA: Inferred from direct assay	12665549	MGI
located in autophagosome	IDA IDA: Inferred from direct assay	12665549	MGI
located in autophagosome membrane	IDA IDA: Inferred from direct assay	21220506	MGI
located in axoneme	IDA IDA: Inferred from direct assay	24089209	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	33087875	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	32210230	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	32210230	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	32210230	MGI
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	12665549	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	33087875	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

autophagy-related protein 16-1

APG16-like 1	Atg16L1 gamma
autophagy-related 16-like 1 gamma

Atg16l1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Atg16l1	Q8C0J2	Atg5	Mus musculus	Q99J83	Y2H	12665549
Intra	Atg16l1	Q8C0J2	Atg5	Mus musculus	Q99J83	Confocal	12665549
Intra	Atg16l1	Q8C0J2	Rb1cc1	Mus musculus	Q9ESK9	Crosslink	23392225

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100008	Peretinoin		99.79%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170998	ATG16L1 stabilizer-1	Inducer	/	Unkown
HY-RS01143	ATG16L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19832	Atg16l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26329	Atg16l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atg16l1	NCBI	NCBI:55054

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