Rb1cc1 - RB1-inducible coiled-coil 1 Gene

Mus musculus

Also known as Cc1; FIP200; LaXp180; 2900055E04Rik; 5930404L04Rik

Gene ID: 12421 | Gene type: protein coding

About Rb1cc1

Summary

Enables protein kinase binding activity. Involved in autophagosome assembly. Acts upstream of or within several processes, including positive regulation of cell size; regulation of signal transduction; and reticulophagy. Located in autophagosome membrane; nucleus; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including heart; musculoskeletal system; nervous system; and trunk paraxial mesenchyme. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]

Rb1cc1 Products(1)

mRNA	Protein	Name
NM_009826.4	NP_033956.2	RB1-inducible coiled-coil protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19258318	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18443221	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	17015619	MGI
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	19225151	MGI
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19258318	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	31006538	MGI
involved in autophagy	IMP IMP: Inferred from mutant phenotype	18443221	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	26764600	MGI
acts upstream of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17015619	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	17015619	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	26764600	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	17015619	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17015619	MGI
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	21795849	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17015619	MGI
acts upstream of or within positive regulation of JNK cascade	IGI IGI: Inferred from genetic interaction	17015619	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	19225151	MGI
acts upstream of or within positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	17015619	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17015619	MGI
acts upstream of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17015619	MGI
involved in regulation of protein lipidation	IDA IDA: Inferred from direct assay	19225151	MGI
acts upstream of or within reticulophagy	IMP IMP: Inferred from mutant phenotype	31006538	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Atg1/ULK1 kinase complex	IDA IDA: Inferred from direct assay	19211835	MGI
part of Atg1/ULK1 kinase complex	IPI IPI: Inferred from physical interaction	19258318	MGI
located in autophagosome membrane	IDA IDA: Inferred from direct assay	31006538	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12095676	MGI
located in phagophore assembly site	IDA IDA: Inferred from direct assay	18936157	MGI
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	18443221	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RB1-inducible coiled-coil protein 1

200 kDa FAK family kinase-interacting protein	FAK family kinase-interacting protein of 200 kDa
coiled-coil-forming protein 1

Rb1cc1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rb1cc1	Q9ESK9	Atg16l1	Mus musculus	Q8C0J2	Anti Bait CoIP	23262492
Intra	Rb1cc1	Q9ESK9	Atg16l1	Mus musculus	Q8C0J2	Crosslink	23392225
Intra	Rb1cc1	Q9ESK9	Atg16l1	Mus musculus	Q8C0J2	Y2H	23392225

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11714	RB1CC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rb1cc1	NCBI	NCBI:9821

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