Syvn1 - synovial apoptosis inhibitor 1, synoviolin Gene

Mus musculus

Also known as Hrd1; 1200010C09Rik; D530017H19Rik

Gene ID: 74126 | Gene type: protein coding

About Syvn1

Summary

Enables ubiquitin protein Ligase activity. Involved in immature B cell differentiation; protein stabilization; and proteolysis involved in cellular protein catabolic process. Acts upstream of or within in utero embryonic development and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum quality control compartment. Is expressed in rib. Orthologous to human SYVN1 (synoviolin 1). [provided by Alliance of Genome Resources, Apr 2022]

Syvn1 Products(2)

mRNA	Protein	Name
NM_001164709.1	NP_001158181.1	E3 ubiquitin-protein ligase synoviolin
NM_028769.5	NP_083045.4	E3 ubiquitin-protein ligase synoviolin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19725872	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21911472	MGI
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	29907570	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	21454652	MGI
involved in immature B cell differentiation	IMP IMP: Inferred from mutant phenotype	29907570	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15611074	MGI
acts upstream of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15611074	MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15611074	MGI
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	20160352	MGI
involved in protein stabilization	IDA IDA: Inferred from direct assay	21454652	MGI
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21911472	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum quality control compartment	IDA IDA: Inferred from direct assay	17707796	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase synoviolin

RING-type E3 ubiquitin transferase synoviolin

synoviolin 1

Syvn1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Syvn1	Q9DBY1	Ncstn	Mus musculus	P57716	Anti Bait CoIP	19725872
Intra	Syvn1	Q9DBY1	Ncstn	Mus musculus	P57716	Anti Tag CoIP	19725872

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135844	LS-102	Inhibitor	/	Unkown
HY-RS14127	SYVN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18845	Syvn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25337	Syvn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syvn1	NCBI	NCBI:84447

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