Izumo1 - izumo sperm-egg fusion 1 Gene

Mus musculus

Also known as Izumo; 1700058F15Rik

Gene ID: 73456 | Gene type: protein coding

About Izumo1

Summary

Enables protein binding activity involved in heterotypic cell-cell adhesion; protein homodimerization activity; and signaling receptor binding activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization; heterotypic cell-cell adhesion; and sperm-egg recognition. Located in acrosomal membrane and plasma membrane. Is integral component of membrane. Orthologous to human IZUMO1 (izumo sperm-egg fusion 1). [provided by Alliance of Genome Resources, Apr 2022]

Izumo1 Products(1)

mRNA	Protein	Name
NM_001018013.1	NP_001018013.1	izumo sperm-egg fusion protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20421979	MGI
enables protein binding involved in heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	35960805	MGI
enables protein binding involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	27309808	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19658160	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	24739963	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fusion of sperm to egg plasma membrane involved in single fertilization	IDA IDA: Inferred from direct assay	15759005	MGI
involved in fusion of sperm to egg plasma membrane involved in single fertilization	IMP IMP: Inferred from mutant phenotype	24739963	MGI
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	27309808	MGI
involved in single fertilization	IMP IMP: Inferred from mutant phenotype	24739963	MGI
involved in sperm-egg recognition	IMP IMP: Inferred from mutant phenotype	24739963	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal membrane	IDA IDA: Inferred from direct assay	19144954	MGI
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	20421979	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	35960805	MGI
located in membrane	IDA IDA: Inferred from direct assay	15759005	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	35960805	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	27624483	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	27309808	MGI
part of protein complex involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	31672133	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

izumo sperm-egg fusion protein 1

OBF	oocyte binding/fusion factor
sperm-specific protein Izumo

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07004	IZUMO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07005	IZUMO1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19263	Izumo1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21242	Izumo1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25752	Izumo1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Izumo1	NCBI	NCBI:284359

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