Ddhd2 - DDHD domain containing 2 Gene

Mus musculus

Also known as SAMWD1; mKIAA0725; 2010305K11Rik

Gene ID: 72108 | Gene type: protein coding

About Ddhd2

Summary

Enables triglyceride Lipase activity. Involved in lipid droplet organization and triglyceride catabolic process. Acts upstream of or within positive regulation of mitochondrial fission. Located in membrane. Used to study hereditary spastic paraplegia 54. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Ddhd2 Products(2)

mRNA	Protein	Name
NM_001361595.2	NP_001348524.1	phospholipase DDHD2 isoform 2
NM_028102.2	NP_082378.1	phospholipase DDHD2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables triacylglycerol lipase activity	IDA IDA: Inferred from direct assay	25267624	MGI
enables triacylglycerol lipase activity	IMP IMP: Inferred from mutant phenotype	25267624	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within lipid droplet organization	IMP IMP: Inferred from mutant phenotype	25267624	MGI
involved in lipid droplet organization	IMP IMP: Inferred from mutant phenotype	25267624	MGI
acts upstream of locomotory behavior	IMP IMP: Inferred from mutant phenotype	25267624	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	25267624	MGI
acts upstream of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	24599962	MGI
acts upstream of or within positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	24599962	MGI
acts upstream of or within triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	25267624	MGI
involved in triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	25267624	MGI
acts upstream of visual learning	IMP IMP: Inferred from mutant phenotype	25267624	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	25267624	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	25267624	MGI
is active in membrane	IMP IMP: Inferred from mutant phenotype	25267624	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipase DDHD2

DDHD domain-containing protein 2

SAM, WWE and DDHD domain-containing protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103060	KLH45	Inhibitor	99.81%	Unkown
HY-115671	KLH45b	Inhibitor	99.99%	Unkown
HY-RS03610	DDHD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20904	Ddhd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27421	Ddhd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddhd2	NCBI	NCBI:23259

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