2. Gene
  3. Cthrc1 - collagen triple helix repeat containing 1 Gene

Cthrc1 - collagen triple helix repeat containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1110014B07Rik

Gene ID: 68588 | Gene type: protein coding

About Cthrc1

Summary

Enables Wnt-protein binding activity and Frizzled binding activity. Acts upstream of or within several processes, including establishment of planar polarity involved in neural tube closure; inner ear development; and ossification involved in bone remodeling. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human CTHRC1 (Collagen triple helix repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Cthrc1 Products(3)

mRNA Protein Name
NM_001364812.1 NP_001351741.1 collagen triple helix repeat-containing protein 1 isoform 2 precursor
NM_001364813.1 NP_001351742.1 collagen triple helix repeat-containing protein 1 isoform 3 precursor
NM_026778.3 NP_081054.1 collagen triple helix repeat-containing protein 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
18606138 MGI
enables frizzled binding IPI
IPI: Inferred from physical interaction
18606138 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18606138 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
18606138 MGI
acts upstream of or within cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
18606138 MGI
acts upstream of or within establishment of planar polarity involved in neural tube closure IGI
IGI: Inferred from genetic interaction
18606138 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
18606138 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18606138 MGI
acts upstream of or within ossification involved in bone remodeling IMP
IMP: Inferred from mutant phenotype
18779865 MGI
acts upstream of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
18779865 MGI
acts upstream of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
18779865 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
18779865 MGI
acts upstream of or within positive regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
18779865 MGI
acts upstream of or within positive regulation of protein binding IDA
IDA: Inferred from direct assay
18606138 MGI
Cellular Component GO Annotation Evidence Reference Source
located in sarcoplasm IDA
IDA: Inferred from direct assay
18467647 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen triple helix repeat-containing protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03297 CTHRC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17347 Cthrc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23801 Cthrc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cthrc1 NCBI NCBI:115908
Rattus norvegicus Cthrc1 NCBI NCBI:282836