2. Gene
  3. Steap3 - STEAP family member 3 Gene

Steap3 - STEAP family member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tsap6; pHyde; 1010001D01Rik

Gene ID: 68428 | Gene type: protein coding

About Steap3

Summary

Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in several structures, including bone; genitourinary system; liver; nervous system; and white fat. Orthologous to human STEAP3 (STEAP3 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]

Steap3 Products(4)

mRNA Protein Name
NM_001085409.2 NP_001078878.1 metalloreductase STEAP3 isoform b
NM_001379354.1 NP_001366283.1 metalloreductase STEAP3 isoform b
NM_001379355.1 NP_001366284.1 metalloreductase STEAP3 isoform a
NM_133186.4 NP_573449.2 metalloreductase STEAP3 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cupric reductase (NADH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
enables ferric-chelate reductase (NADPH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
enables ferric-chelate reductase (NADPH) activity IMP
IMP: Inferred from mutant phenotype
18955558 MGI
enables ferric-chelate reductase activity IDA
IDA: Inferred from direct assay
16227996 MGI
enables ferric-chelate reductase activity IMP
IMP: Inferred from mutant phenotype
16227996 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26642240 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within copper ion import IDA
IDA: Inferred from direct assay
16609065 MGI
acts upstream of or within copper ion import IMP
IMP: Inferred from mutant phenotype
18955558 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
16227996 MGI
acts upstream of or within exosomal secretion IMP
IMP: Inferred from mutant phenotype
18617898 MGI
acts upstream of or within iron import into cell IDA
IDA: Inferred from direct assay
16609065 MGI
acts upstream of or within iron ion import across cell outer membrane IDA
IDA: Inferred from direct assay
16609065 MGI
acts upstream of or within iron ion import across cell outer membrane IMP
IMP: Inferred from mutant phenotype
18955558 MGI
acts upstream of or within iron ion transport IMP
IMP: Inferred from mutant phenotype
16227996 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
18617898 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endosome IDA
IDA: Inferred from direct assay
16227996 MGI
located in endosome membrane IMP
IMP: Inferred from mutant phenotype
18955558 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16227996 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloreductase STEAP3

dudulin 2

protein nm1054

six-transmembrane epithelial antigen of prostate 3

tumor suppressor-activated pathway protein 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13908 STEAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17857 Steap3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24326 Steap3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Steap3 NCBI NCBI:55240