Serpina12 - serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Gene

Mus musculus

Also known as 4632419J12Rik

Gene ID: 68054 | Gene type: protein coding

About Serpina12

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of gluconeogenesis; positive regulation of signal transduction; and regulation of lipid metabolic process. Located in extracellular space and plasma membrane. Is expressed in back skin. Orthologous to human SERPINA12 (Serpin family A member 12). [provided by Alliance of Genome Resources, Apr 2022]

Serpina12 Products(1)

mRNA	Protein	Name
NM_026535.2	NP_080811.1	serpin A12 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22837305	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of gluconeogenesis	IDA IDA: Inferred from direct assay	22837305	MGI
acts upstream of lipid biosynthetic process	IDA IDA: Inferred from direct assay	22837305	MGI
acts upstream of or within negative regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	22837305	MGI
acts upstream of or within negative regulation of lipid biosynthetic process	IDA IDA: Inferred from direct assay	22837305	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22837305	MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22837305	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22837305	MGI
acts upstream of or within regulation of cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	22837305	MGI
acts upstream of or within regulation of triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	22837305	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	22837305	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	22837305	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serpin A12

serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	vaspin
visceral adipose tissue-derived serine protease inhibitor	visceral adipose-specific SERPIN

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12698	SERPINA12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20676	Serpina12 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Serpina12	NCBI	NCBI:145264

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