Kat8 - K(lysine) acetyltransferase 8 Gene

Mus musculus

Also known as MOF; Myst1; MYST-1; D7Ertd629e; 2010203C02Rik; 5830450F21Rik

Gene ID: 67773 | Gene type: protein coding

About Kat8

Summary

Enables enzyme binding activity and Histone Acetyltransferase activity (H4-K16 specific). Involved in histone H4-K16 acetylation. Located in kinetochore and nuclear matrix. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; limb; nervous system; and respiratory system. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]

Kat8 Products(2)

mRNA	Protein	Name
NM_001360699.1	NP_001347628.1	histone acetyltransferase KAT8 isoform 2
NM_026370.2	NP_080646.1	histone acetyltransferase KAT8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyltransferase activity	IDA IDA: Inferred from direct assay	19578370	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	19578370	MGI
enables histone H4K16 acetyltransferase activity	IDA IDA: Inferred from direct assay	24898753	MGI
enables histone H4K16 acetyltransferase activity	IMP IMP: Inferred from mutant phenotype	23523075	MGI
enables peptide-lysine-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	30842237	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	23523075	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17335777	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in dosage compensation by inactivation of X chromosome	IDA IDA: Inferred from direct assay	24842875	MGI
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	30842237	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	31794431	MGI
involved in oogenesis	IDA IDA: Inferred from direct assay	28506985	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24842875	MGI
involved in positive regulation of skeletal muscle satellite cell differentiation	IDA IDA: Inferred from direct assay	34059674	MGI
involved in post-embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	27827827	MGI
involved in regulation of mitochondrial transcription	IDA IDA: Inferred from direct assay	27768893	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of MSL complex	IDA IDA: Inferred from direct assay	24842875	MGI
part of MSL complex	IMP IMP: Inferred from mutant phenotype	23523075	MGI
part of NSL complex	IDA IDA: Inferred from direct assay	24842875	MGI
is active in chromosome	IDA IDA: Inferred from direct assay	24898753	MGI
located in kinetochore	IDA IDA: Inferred from direct assay	14519686	MGI
is active in mitochondrion	IDA IDA: Inferred from direct assay	37813994	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	27768893	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	21746928	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	28506985	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histone acetyltransferase KAT8

MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1	MYST histone acetyltransferase 1
histone acetyltransferase Myst1	lysine acetyltransferase 8
probable histone acetyltransferase MYST1

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149302	MC4033		98.26%	Unkown
HY-W015239	KAT8-IN-1		99.40%	Unkown
HY-153604	MC4171	Inhibitor	98.68%	Unkown
HY-168428	CHI-KAT8i5		98.00%	Unkown
HY-RS07084	KAT8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17587	Kat8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24047	Kat8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kat8	NCBI	NCBI:84148

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