Chd8 - chromodomain helicase DNA binding protein 8 Gene

Mus musculus

Also known as Chd-8; Duplin; HELSNF1; mKIAA1564; 5830451P18Rik

Gene ID: 67772 | Gene type: protein coding

About Chd8

Summary

This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene causes early embryonic lethality due to widespread Apoptosis. Heterozygous loss of function mutations result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016]

Chd8 Products(1)

mRNA	Protein	Name
NM_201637.3	NP_963999.2	chromodomain-helicase-DNA-binding protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19151705	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	27602517	MGI
enables histone binding	IDA IDA: Inferred from direct assay	19151705	MGI
enables histone binding	IPI IPI: Inferred from physical interaction	22083958	MGI
enables p53 binding	IPI IPI: Inferred from physical interaction	19151705	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16949368	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	27602517	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	27602517	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15367660	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19151705	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19151705	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15367660	MGI
acts upstream of or within negative regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	19151705	MGI
acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	27602517	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	27602517	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	27602517	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19151705	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chromodomain-helicase-DNA-binding protein 8

ATP-dependent helicase CHD8	axis duplication inhibitor
helicase with SNF2 domain 1

Chd8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Chd8	Q09XV5	Cebpb	Mus musculus	P28033	Anti Bait CoIP	29768199
Intra	Chd8	Q09XV5	Ctcf	Mus musculus	Q61164	Pull Down	16949368

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02613	CHD8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chd8	NCBI	NCBI:57680

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