2. Gene
  3. Ctcf - CCCTC-binding factor Gene

Ctcf - CCCTC-binding factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 13018 | Gene type: protein coding

About Ctcf

Summary

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of histone modification. Acts upstream of or within DNA metabolic process and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 21. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Apr 2022]

Ctcf Products(12)

mRNA Protein Name
NM_001358924.2 NP_001345853.1 transcriptional repressor CTCF isoform 2
NM_001403723.1 NP_001390652.1 transcriptional repressor CTCF isoform 1
NM_001403724.1 NP_001390653.1 transcriptional repressor CTCF isoform 1
NM_001403725.1 NP_001390654.1 transcriptional repressor CTCF isoform 1
NM_001403726.1 NP_001390655.1 transcriptional repressor CTCF isoform 2
NM_001403727.1 NP_001390656.1 transcriptional repressor CTCF isoform 2
NM_001403728.1 NP_001390657.1 transcriptional repressor CTCF isoform 2
NM_001403729.1 NP_001390658.1 transcriptional repressor CTCF isoform 3
NM_001403730.1 NP_001390659.1 transcriptional repressor CTCF isoform 3
NM_001403731.1 NP_001390660.1 transcriptional repressor CTCF isoform 4
NM_001403732.1 NP_001390661.1 transcriptional repressor CTCF isoform 4
NM_181322.4 NP_851839.1 transcriptional repressor CTCF isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
12461525 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22780989 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28636939 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16949368 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11743158 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA methylation-dependent heterochromatin formation IMP
IMP: Inferred from mutant phenotype
24105743 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
28846746 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
28846746 MGI
involved in chromatin looping IDA
IDA: Inferred from direct assay
28388437 MGI
involved in chromatin looping IMP
IMP: Inferred from mutant phenotype
16951251 MGI
acts upstream of or within chromatin organization IMP
IMP: Inferred from mutant phenotype
28846746 MGI
acts upstream of or within epigenetic regulation of gene expression IDA
IDA: Inferred from direct assay
12461525 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
28846746 MGI
acts upstream of or within genomic imprinting IDA
IDA: Inferred from direct assay
12461525 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
14716017 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
28846746 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
28846746 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
28846746 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18614575 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: Inferred from mutant phenotype
14716017 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24105743 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18614575 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15143173 MGI
Cellular Component GO Annotation Evidence Reference Source
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
12011441 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12075007 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional repressor CTCF

11-zinc finger protein

CTCFL paralog

Ctcf Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Ctcf Q61164 Chd8 Mus musculus Q09XV5
Y2H
16949368
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03287 CTCF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17635 Ctcf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24095 Ctcf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctcf NCBI NCBI:10664