2. Gene
  3. Ctnnbip1 - catenin beta interacting protein 1 Gene

Ctnnbip1 - catenin beta interacting protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Icat; Catnbip1; 1110008O09Rik; 2310001I19Rik

Gene ID: 67087 | Gene type: protein coding

About Ctnnbip1

Summary

Enables beta-catenin binding activity. Involved in several processes, including negative regulation of DNA binding activity; negative regulation of smooth muscle cell proliferation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; negative regulation of Wnt signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human CTNNBIP1 (catenin beta interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctnnbip1 Products(2)

mRNA Protein Name
NM_001141930.1 NP_001135402.1 beta-catenin-interacting protein 1
NM_023465.4 NP_075954.1 beta-catenin-interacting protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12408824 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10898789 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15148409 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17803964 MGI
involved in negative regulation of DNA binding IDA
IDA: Inferred from direct assay
11751639 MGI
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11751639 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
15148409 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IPI
IPI: Inferred from physical interaction
10898789 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10898789 MGI
involved in negative regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
11751639 MGI
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17122440 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16678101 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10898789 MGI
involved in negative regulation of transcription initiation by RNA polymerase II IDA
IDA: Inferred from direct assay
11751639 MGI
Cellular Component GO Annotation Evidence Reference Source
part of beta-catenin-ICAT complex IPI
IPI: Inferred from physical interaction
10898789 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-catenin-interacting protein 1

inhibitor of beta-catenin and Tcf-4

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03309 CTNNBIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22063 Ctnnbip1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctnnbip1 NCBI NCBI:56998