Mcub - mitochondrial calcium uniporter dominant negative beta subunit Gene

Mus musculus

Also known as Ccdc109b; 9030408N13Rik

Gene ID: 66815 | Gene type: protein coding

About Mcub

Summary

Enables Calcium Channel Inhibitor activity. Involved in mitochondrial calcium ion homeostasis and mitochondrial calcium ion transmembrane transport. Located in mitochondrion. Is intrinsic component of membrane. Part of Calcium Channel complex. Orthologous to human MCUB (mitochondrial calcium uniporter dominant negative subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Mcub Products(2)

mRNA	Protein	Name
NM_001293644.2	NP_001280573.2	calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2
NM_025779.4	NP_080055.3	calcium uniporter regulatory subunit MCUb, mitochondrial isoform1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel inhibitor activity	IDA IDA: Inferred from direct assay	23900286	MGI
NOT enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	23900286	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23900286	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	23900286	MGI
involved in mitochondrial calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	23900286	MGI
involved in negative regulation of calcium import into the mitochondrion	IDA IDA: Inferred from direct assay	31533452	MGI
involved in positive regulation of skeletal muscle satellite cell differentiation	IMP IMP: Inferred from mutant phenotype	34726954	MGI
involved in regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	34726954	MGI
involved in skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	34726954	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	23900286	MGI
located in membrane	IDA IDA: Inferred from direct assay	23900286	MGI
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	23900286	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calcium uniporter regulatory subunit MCUb, mitochondrial

coiled-coil domain containing 109B	coiled-coil domain-containing protein 109B
mitochondrial calcium uniporter regulatory subunit MCUb

Mcub Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mcub	Q810S1	Mcu	Mus musculus	Q3UMR5	Anti Tag CoIP	23900286
Intra	Mcub	Q810S1	Mcu	Mus musculus	Q3UMR5	FRET	23900286

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08253	MCUB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20771	Mcub Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27285	Mcub Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mcub	NCBI	NCBI:55013

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