2. Gene
  3. Map1lc3a - microtubule-associated protein 1 light chain 3 alpha Gene

Map1lc3a - microtubule-associated protein 1 light chain 3 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as LC3; LC3a; 1010001H21Rik; 4922501H04Rik

Gene ID: 66734 | Gene type: protein coding

About Map1lc3a

Summary

Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein Ligase binding activity. Predicted to be involved in Autophagy of mitochondrion; cellular response to nitrogen starvation; and macroautophagy. Located in autophagosome membrane. Is expressed in several structures, including central nervous system; heart; limb; peripheral nervous system ganglion; and sensory organ. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Map1lc3a Products(1)

mRNA Protein Name
NM_025735.3 NP_080011.1 microtubule-associated proteins 1A/1B light chain 3A
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14530254 MGI
Cellular Component GO Annotation Evidence Reference Source
located in autophagosome IDA
IDA: Inferred from direct assay
15755735 MGI
located in autophagosome membrane IDA
IDA: Inferred from direct assay
21220506 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule-associated proteins 1A/1B light chain 3A

MAP1 light chain 3-like protein 1

MAP1A/MAP1B LC3 A

MAP1A/MAP1B light chain 3 A

autophagy-related protein LC3 A

autophagy-related ubiquitin-like modifier LC3 A

Map1lc3a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Map1lc3a Q91VR7 Disc1 Mus musculus Q811T9
Anti Bait CoIP
30488644
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08028 MAP1LC3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21273 Map1lc3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27792 Map1lc3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map1lc3a NCBI NCBI:84557