Exosc3 - exosome component 3 Gene

Mus musculus

Also known as Rrp40; 2310005D06Rik

Gene ID: 66362 | Gene type: protein coding

About Exosc3

Summary

Predicted to enable RNA binding activity. Involved in isotype switching. Acts upstream of or within positive regulation of isotype switching. Predicted to be located in cytoplasm; nuclear lumen; and transcriptionally active chromatin. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1B. Orthologous to human EXOSC3 (exosome component 3). [provided by Alliance of Genome Resources, Apr 2022]

Exosc3 Products(2)

mRNA	Protein	Name
NM_001362788.1	NP_001349717.1	exosome complex component RRP40 isoform 2
NM_025513.4	NP_079789.1	exosome complex component RRP40 isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in isotype switching	IMP IMP: Inferred from mutant phenotype	21255825	MGI
acts upstream of or within positive regulation of isotype switching	IMP IMP: Inferred from mutant phenotype	21255825	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

exosome complex component RRP40

exosome complex exonuclease RRP40

ribosomal RNA-processing protein 40

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139059	ERD03	Inhibitor	99.39%	Unkown
HY-RS04599	EXOSC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21124	Exosc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27643	Exosc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Exosc3	NCBI	NCBI:51010

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