Aacs - acetoacetyl-CoA synthetase Gene

Rattus norvegicus

Gene ID: 65984 | Gene type: protein coding

About Aacs

Summary

Enables acetoacetate-CoA Ligase activity and butyrate-CoA Ligase activity. Involved in several processes, including cellular response to glucose stimulus; cellular response to lipid; and positive regulation of Insulin secretion. Located in cytosol. Biomarker of obesity. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Aacs Products(1)

mRNA	Protein	Name
NM_023104.2	NP_075592.1	acetoacetyl-CoA synthetase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetoacetate-CoA ligase activity	IDA IDA: Inferred from direct assay	3082367	RGD
enables short-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	6539623	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adipose tissue development	IEP IEP: Inferred from expression pattern	16055091	RGD
involved in cellular response to cholesterol	IEP IEP: Inferred from expression pattern	3663886	RGD
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	17724028	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	19085696	RGD
involved in liver development	IDA IDA: Inferred from direct assay	10513626	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17724028	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	8104400	RGD
involved in response to nutrient	IDA IDA: Inferred from direct assay	3082367	RGD
involved in response to oleic acid	IDA IDA: Inferred from direct assay	2565110	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	3082367	RGD
involved in response to purine-containing compound	IEP IEP: Inferred from expression pattern	6501306	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	33671	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	12034369	RGD
involved in white fat cell differentiation	IEP IEP: Inferred from expression pattern	16055091	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acetoacetyl-CoA synthetase

AcAc-CoA ligase	acetoacetate-CoA ligase
acetoacetyl-CoA ligase

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0124	Zonisamide	Inhibitor	99.85%	Yes
HY-B0124A	Zonisamide sodium	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14880B	Bavisant dihydrochloride hydrate	Antagonist	99.26%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171414	MC-VC-PAB-O-Gemcitabine		96.78%	Unkown
HY-161886	SMARCA2-IN-7	Inhibitor	/	Unkown
HY-161887	SMARCA2-IN-8	Inhibitor	/	Unkown
HY-RS00016	AACS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B0124S2	Zonisamide-13C6	Inhibitor	/	Unkown
HY-RS22091	Aacs Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28611	Aacs Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aacs	NCBI	NCBI:65985

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