MC-VC-PAB-O-Gemcitabine

Cat. No.: HY-171414: Data Sheet Handling Instructions
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MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate, which is part of the antibody-antibiotic conjugate (AAC) molecule. MC-VC-PAB-O-Gemcitabine is conjugated with the linker and the antibiotic Gemcitabine (HY-17026). MC-VC-PAB-O-Gemcitabine can be used to study the immunotherapy of bacterial infections and the development of new antibacterial drugs.

For research use only. We do not sell to patients.

MC-VC-PAB-O-Gemcitabine Chemical Structure

CAS No. : 1639430-82-2

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MOQ		Minimum order quantity
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100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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Description

Molecular Weight

861.85

Formula

C₃₈H₄₉F₂N₉O₁₂

CAS No.

1639430-82-2

Appearance

Solid

SMILES

FC1(F)[C@H](O)[C@@H](COC(OCC2=CC=C(C=C2)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN3C(C=CC3=O)=O)=O)=O)=O)=O)O[C@H]1N4C=CC(N)=NC4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (116.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1603 mL	5.8015 mL	11.6029 mL
5 mM	0.2321 mL	1.1603 mL	2.3206 mL
10 mM	0.1160 mL	0.5801 mL	1.1603 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Eric J. Brown, et al. Anti-wall teichoic antibodies and conjugates. WO2014193722. US. 2014-05-22

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1603 mL	5.8015 mL	11.6029 mL	29.0074 mL
	5 mM	0.2321 mL	1.1603 mL	2.3206 mL	5.8015 mL
	10 mM	0.1160 mL	0.5801 mL	1.1603 mL	2.9007 mL
	15 mM	0.0774 mL	0.3868 mL	0.7735 mL	1.9338 mL
	20 mM	0.0580 mL	0.2901 mL	0.5801 mL	1.4504 mL
	25 mM	0.0464 mL	0.2321 mL	0.4641 mL	1.1603 mL
	30 mM	0.0387 mL	0.1934 mL	0.3868 mL	0.9669 mL
	40 mM	0.0290 mL	0.1450 mL	0.2901 mL	0.7252 mL
	50 mM	0.0232 mL	0.1160 mL	0.2321 mL	0.5801 mL
	60 mM	0.0193 mL	0.0967 mL	0.1934 mL	0.4835 mL
	80 mM	0.0145 mL	0.0725 mL	0.1450 mL	0.3626 mL
	100 mM	0.0116 mL	0.0580 mL	0.1160 mL	0.2901 mL